Stereoselective total synthesis of (-)-kumausallene.
نویسندگان
چکیده
A stereoselective total synthesis of (-)-kumausallene was completed in 12 steps from acetylacetone. The hidden symmetry of (-)-kumausallene was recognized, and its skeleton was constructed efficiently from a C(2)-symmetric diol by a palladium-catalyzed cascade reaction. High diastereoselectivity was observed for the DMF-promoted biomimetic 1,4-bromocyclization of a conjugated enyne.
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ورودعنوان ژورنال:
- Organic letters
دوره 13 14 شماره
صفحات -
تاریخ انتشار 2011